Frauke Christ Selected Research

lens epithelium-derived growth factor

1/2022	LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators.
1/2021	Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.
1/2021	LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection.
1/2019	Impact of LEDGIN treatment during virus production on residual HIV-1 transcription.
1/2018	LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.
1/2018	Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
6/2017	Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets.
1/2013	The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.
3/2012	The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity.
1/2012	Cellular cofactors of lentiviral integrase: from target validation to drug discovery.

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Frauke Christ Research Topics

Disease

15	Infections 10/2021 - 02/2006
8	HIV Infections (HIV Infection) 01/2021 - 01/2012
6	Leukemia 01/2022 - 01/2016
6	Acquired Immunodeficiency Syndrome (AIDS) 12/2018 - 03/2012
5	Neoplasms (Cancer) 01/2022 - 09/2007
2	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 03/2012
2	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2019 - 06/2014
1	Cystic Fibrosis (Mucoviscidosis) 04/2022
1	Type 1F Limb-Girdle Muscular Dystrophy 01/2019
1	Chronic Disease (Chronic Diseases) 12/2018
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 06/2014
1	Inflammation (Inflammations) 03/2012
1	Osteosarcoma (Osteogenic Sarcoma) 03/2012
1	Disease Progression 09/2011

Drug/Important Bio-Agent (IBA)

13	lens epithelium-derived growth factorIBA 01/2022 - 12/2006
4	Antiviral Agents (Antivirals)IBA 01/2021 - 01/2012
4	IntegrasesIBA 01/2020 - 12/2006
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2007
3	Human immunodeficiency virus 1 p31 integrase proteinIBA 01/2021 - 10/2011
3	Pharmaceutical PreparationsIBA 01/2019 - 06/2014
2	ChromatinIBA 01/2021 - 01/2016
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 04/2022
1	fms-Like Tyrosine Kinase 3IBA 01/2022
1	enhanced green fluorescent proteinIBA 01/2020
1	Complement System Proteins (Complement)IBA 01/2020
1	Serine (L-Serine)FDA Link 01/2019
1	Codon (Codons)IBA 01/2019
1	NucleotidesIBA 01/2019
1	Arginine (L-Arginine)FDA Link 01/2019
1	RNA Splicing FactorsIBA 01/2019
1	HIV IntegraseIBA 01/2019
1	Karyopherins (Importin)IBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2018
1	Viral DNAIBA 01/2017
1	Human Immunodeficiency Virus ProteinsIBA 01/2017
1	RNA (Ribonucleic Acid)IBA 02/2015
1	LigandsIBA 04/2014
1	Integrase InhibitorsIBA 12/2013
1	AutoantigensIBA 03/2012
1	Transcription Factors (Transcription Factor)IBA 03/2012
1	Viral ProteinsIBA 01/2012
1	Raltegravir Potassium FDA Link 10/2011
1	Messenger RNA (mRNA)IBA 09/2011
1	Complementary DNA (cDNA)IBA 02/2006

Therapy/Procedure

3	Highly Active Antiretroviral Therapy (HAART) 10/2021 - 12/2018
2	Therapeutics 01/2021 - 12/2018